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近15年来研究证实,钙拮抗剂对心肌的保护作用是维护其机械功能、ATP 在组织中的储备和线粒体功能,它还能减少经病理解剖、心电图和酶学检查测算的实验性冠状动脉闭塞引起的梗塞范围。现已认为冠状动脉收缩或痉挛是急性心肌梗塞(AMI)发病原因之一,钙拮抗剂则是有效的冠状动脉扩张剂,能治疗血管痉挛性心绞痛,且具有抗再灌注时的心律失常作用。本文主要是自拟诊 AMI起经6个月的异搏停双盲随机安慰剂对照研究,以确定其是否可减少任何原因的死亡率
In the past 15 years, studies have confirmed that the protective effect of calcium antagonists on myocardium is to maintain its mechanical function, ATP’s reserve in tissues and mitochondrial function. It can also reduce the experimental coronary occlusion measured by pathological anatomy, electrocardiogram and enzymology examination Cause infarct range. It is thought that coronary artery contraction or spasm is one of the causes of acute myocardial infarction (AMI). Calcium antagonists are effective coronary dilators, which can treat angina spastic angina and have antiarrhythmic effects during reperfusion. This article is primarily a double-blind, randomized, placebo-controlled study of infliximab taken six months after initial diagnosis of AMI to determine if it can reduce any cause mortality