论文部分内容阅读
目的：研究大肠癌患者血清及癌细胞内胃泌素水平，探讨胃泌素（Ｇａｓｔｒｉｎ）对大肠癌（ＬＩＣ）的作用及其临床意义。方法：采用放射免疫法检测３５例大肠癌患者血清和癌细胞及癌旁粘膜细胞内胃泌素水平。结果：大肠癌患者术前、术后血清胃泌素含量与对照组差异不显著，根治术后明显低于术前（Ｐ＜０．０１），在高分化和中分化腺癌组中差异显著（Ｐ＜０．０５）。大肠癌细胞内胃泌素水平明显高于癌旁粘膜（Ｐ＜０．０１）和正常粘膜（Ｐ＜０．０５），高分化腺癌明显高于低分化和粘液腺癌（Ｐ＜０．０５）。大肠癌患者血清及癌细胞内胃泌素水平与Ｄｕｋｅ′ｓ分期无关。结论：大肠癌细胞主要通过自分泌方式产生胃泌素，胃泌素升高是大肠癌分化良好的标志。
Objective: To study the level of gastrin in serum and cancer cells of patients with colorectal cancer and to investigate the effect of gastrin on colorectal cancer (LIC) and its clinical significance. METHODS: Gastrin levels in serum and cancer cells and paraneoplastic mucosa were measured in 35 patients with colorectal cancer by radioimmunoassay. Results: There was no significant difference in preoperative and postoperative serum gastrin levels between patients with colorectal cancer and the control group. The postoperative gastrectomy was significantly lower than that before operation (P<0.01). There was a significant difference between the well-differentiated and moderately differentiated adenocarcinoma groups. (P<0.05). The level of gastrin in colorectal cancer cells was significantly higher than that in adjacent mucosa (P<0.01) and normal mucosa (P<0.05), and well-differentiated adenocarcinoma was significantly higher than poorly differentiated and mucinous adenocarcinoma (P<0. 05). Gastrin levels in serum and cancer cells of patients with colorectal cancer were not related to Duke’s stage. Conclusion: Colorectal cancer cells produce gastrin mainly through autocrine. Gastrin elevation is a sign of good differentiation of colorectal cancer.