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用原位杂交法对孤束核尾侧部内生长抑素ｍＲＮＡ（ＳＯＭｍＲＶＡ）的分布进行了研究。ＳＯＭｍＲＮＡ位于不同平面孤束核内的神经元胞体和近端树突中，从ＳＯＭｍＲＮＡ阳性神经元一般为中小型细胞，呈圆形或椭圆形，分布于孤束核的内侧亚核、背侧亚核、背外侧亚核、连合亚核、中间亚核、腹侧亚枝和腹外侧亚核，其中以最后区上段及其吻侧平面的孤束核的内侧亚核、连合亚核、背侧亚核和背外侧亚核最为多见。结果提示ＳＯＭｍＲＮＡ阳性神经元在该核尾侧部各亚核内的广泛分布可能与该核参与对血压、心血管、呼吸、胃肠道等内脏活动的中枢控制有密切关系。生长抑素作为一种神经调制物可能在上述孤束核参与的植物性神经复杂整合功能中起着重要的作用。
The distribution of somatostatin mRNA (SOMmRVA) in the caudal part of the nucleus tractus solitarius was studied by in situ hybridization. SOMmRNAs are located in neurons and proximal dendrites in different plane solitary nucleus. SOM mRNA positive neurons are generally small and medium cells, round or oval, located in the medial subnucleus of nucleus tractus solitarius, dorsal and inferior Nucleus, dorsolateral nucleus, commissural subnuclear, middle subnuclear, ventral subdiaphragmatic and ventral subnuclear, in which the medial subnucleus of the nucleus tractus solitarius in the upper part of the last region and its kiss flank plane, Dorsal and dorsal sub-nuclear sub-nuclear most common. The results suggest that the widespread distribution of SOM mRNA positive neurons in each subnucleus of the caudal part of the nucleus may be closely related to the central involvement of the nucleus in visceral activities such as blood pressure, cardiovascular, respiratory and gastrointestinal tract. Somatostatin as a neuromodulator may play an important role in the complex function of autonomic nerve complex involved in solitary tract nucleus.