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本文对肾上腺素（Ｅ）大剂量（ＨＤＥ）与标准量（ＳＤＥ）静脉注射在心肺复苏（ＣＰＲ）时疗效进行评价。１３６例心脏骤停（ＣＡ）或依Ｅ用量不同分为两组。ＨＤＥ组（ｎ＝２４）首剂量１ｍｇ后，每隔３～５分钟重复２～８ｍｇ，累积量最小６ｍｇ，最大２２ｍｇ，平均量（ｘ±Ｓ）１０．２０±０．７８ｍｇ；ＳＤＥ组（ｎ＝１１２）首剂量１ｍｇ，３～５分钟重复首剂量。对两组自主循环恢复（ＲＳＣ）率及存活率进行对照，结果ＨＤＥ组ＲＳＣ率（９／２４）明显高于ＳＤＥ组（１７／１１２），具有显著统计学差异（Ｐ＜０．０５）；ＨＤＥ组在活率（１／２４）与ＳＤＥ组（６／１１２）对照无显著统计学差异（Ｐ＞０．０５）。７例存活者病因主要是中毒、原发室颤、电击与溺水。本研究证明：ＨＤＥ可显著提高ＲＳＣ率，而与存活率似乎无关，存活率与ＣＡ的病因学及是否早期采用有效的ＣＰＲ综合措施有关。
This article evaluates the efficacy of high-dose (HDE) and standard-dose (SDE) intravenous epinephrine in cardiopulmonary resuscitation (CPR). 136 cases of cardiac arrest (CA) or depending on the amount of E divided into two groups. HDE group (n = 24), the first dose of 1mg repeated every 3 to 5 minutes 2 ~ 8mg, the cumulative amount of 6mg, the maximum 22mg, the average amount of (x ± S) 10.20 ± 0.78mg; SDE group = 112) The first dose of 1mg, 3 to 5 minutes to repeat the first dose. The RSC rate and survival rate of the two groups were compared. The results showed that the RSC rate (9/24) in HDE group was significantly higher than that in SDE group (17/112), with significant difference (P <0.05). No significant difference was found between HDE group (1/24) and SDE group (6/112) (P> 0.05). The main cause of the seven survivors was poisoning, primary VF, electric shock and drowning. This study demonstrates that: HDE can significantly improve the RSC rate, but nothing to do with the survival rate, the survival rate and CA etiology and whether the early use of effective CPR comprehensive measures.