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为了探索国产甲型肝炎 (甲肝 )减毒活疫苗不同剂量、不同免疫程序的免疫效果 ,并与甲肝灭活疫苗进行比较 ,在河北省正定县某乡 3个村筛选 3～ 13岁的甲肝易感儿童 2 11名 ,按年龄分层随机分为甲肝减毒活疫苗A组(0、6、12个月 )、B组 (0、6个月 )和甲肝灭活疫苗C组 (0、6个月 )。这 3个组按不同免疫程序减毒活疫苗或灭活疫苗免疫后 1、6、7、12、13、2 4个月采血 ,检测抗甲肝病毒抗体 (抗 -HAV)。结果显示 :A、B、C 3个组在首剂疫苗免疫后 1个月时抗 -HAV阳转率均较低 (33 87%～ 42 2 2 % ) ;第 2剂疫苗免疫后 1个月抗体水平均有大幅度提高 ,抗-HAV阳转率为 97 6 7%～ 10 0 0 0 % ,几何平均滴度 (GMT)为 110 7 16mIU/ml～ 2 477 5 2mIU/ml,升高 2 0倍以上 ;首剂免疫后 12个月抗 -HAV阳性率均为 10 0 0 0 % ,但GMT下降了 6 4 9%～ 5 7 0 %。仅A组首剂免疫后 12个月时注射了第 3剂减毒活疫苗 ,1个月后抗体GMT呈 5 7倍增长。首剂免疫后 2 4个月时 ,3个组抗 -HAV阳性率为 92 98%～ 98 11% ,GMT为 2 13 87～ 6 42 6 9mIU/ml。低滴度减毒活疫苗基础免疫后再免疫能诱导很好的免疫回忆反应
In order to explore the different doses of domestic live attenuated Hepatitis A (A) live attenuated vaccine and immune effects of different immunization programs, and compared with hepatitis A inactivated vaccine, a village in Zhengding County, Hebei Province, 3 villages of 3 to 13-year-old screening of hepatitis A A total of 2 11 children with sensory impairment were randomly divided into group A (0, 6 and 12 months), group B (0 and 6 months) and group A (0 and 6 Month). The three groups were immunized with live attenuated or inactivated vaccines of different immunization programs at 1,6,7,12,13,24 months after immunization to detect anti-HAV antibody (anti-HAV). The results showed that the positive rate of anti-HAV was lower in group A, B and C at 1 month after the first dose of vaccine (33 87% -42 2 2%), and one month after the second dose of vaccine Antibody levels were significantly increased, anti-HAV positive rate of 97 6 7% to 10 0 0%, the geometric mean titer (GMT) of 110 7 16mIU / ml ~ 2 477 5 2mIU / ml, increased 2 The positive rate of anti-HAV was 10 0 0% at 12 months after the first dose of immunization, but the GMT decreased by 6 4 9% -5 70%. Only Group A first dose of 12 months after the injection of the third attenuated live vaccine, antibody GMT after a month showed a 5 7 fold increase. At 24 months after the first dose of immunization, the positive rates of anti-HAV in three groups were 92 98% -98 11% and GMT was 2 13 87-6 42 6 9 mIU / ml. Low-titer Live Attenuated Vaccine Basal Immunization Re-immunization can induce good immune recall responses