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目的：探讨幽门螺杆菌（Ｈｐ）、乙型肝炎病毒（ＨＢＶ）感染与消化性溃疡（ＰＵ）的关系及ＨＢＶ致ＰＵ的机制；方法：３６８例接受内镜检查，同时行胃粘膜快速尿毒酶Ｈｐ检测和血清ＨＢＶ标记物（ＨＢＶ－Ｍ）检测的住院患者。并对结果进行Ｘ２检验；结果：３６８例中检出ＰＵ１５０例（４３．２１％），其中：①胃粘膜Ｈｐ（＋）与Ｈｐ（－）组ＰＵ检出率为４７．４％和２１．４７％，两组比较有极显著差异（ｐ＜０．０５）。②血清ＨＢＶ－Ｍ（＋）与ＨＢＶ－Ｍ（－）组ＰＵ检出率为５５．７１％和４０．２７％，两组比较有显著性差异（ｐ＜０．０２５）。③Ｈｐ（＋）＋ＨＢＶ－Ｍ（＋）与Ｈｐ（＋）＋ＨＢＶ（－）组ＰＵ检出率为６１．４％和４３．９７％，两组比较有显著性差异（ｐ＜０．０２５）；④Ｈｐ（－）＋ＨＢＶ－Ｍ（＋）与Ｈｐ（－）＋ＨＢＶ－Ｍ（－）组ＰＵ检出率为３０．７％和２７．２％，两组比较无显著性差异（ｐ＞０．７５）；结论：Ｈｐ是ＰＵ的主要发病因素，ＨＢＶ感染与ＰＵ有密切关系，是参与ＰＵ发病的因素之一。当Ｈｐ合并ＨＢＶ感染时，ＰＵ检出率增高
Objective: To investigate the relationship between Helicobacter pylori (Hp), hepatitis B virus (HBV) infection and peptic ulcer (PU) and the mechanism of HBV induced PU.Methods: 368 cases underwent endoscopy and gastric mucosal rapid urease Hp test and serum HBV markers (HBV-M) test of hospitalized patients. (43.21%) were detected in 368 cases, of which: (1) The detection rates of PU in Hp (+) and Hp (-) groups were 47.4% and 21.2. 47%, there was a significant difference between the two groups (p <0.05). ② The detection rates of PU in serum HBV-M (+) and HBV-M (-) groups were 55.71% and 40.27%, respectively. There was significant difference between the two groups (p <0.025). ③ The detection rates of PU in Hp (+) + HBV-M (+) and Hp (+) + HBV (-) groups were 61.4% and 43.97%, respectively, with significant difference between the two groups (p <0.025) (4) The detection rates of PU in Hp (-) + HBV-M (+) and Hp (-) + HBV-M (-) groups were 30.7% and 27.2%, with no significant difference ). Conclusion: Hp is the main risk factor of PU. HBV infection is closely related to PU and is one of the factors involved in the pathogenesis of PU. When Hp with HBV infection, PU detection rate increased