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采用较先进的放射免疫分析法测量41例胆色素结石病人和31例正常人血清生长激素和胰岛素的水平，结果显示病人血清中生长激素明显高于对照组（P＜0．001），而胰岛素水平低于对照组（P＞0．05）.基于这一发现，作者推测，胆色素结石的形成与生长激素的升高可能有一定的内在联系，其机理可能是：生长激素能够刺激甲状旁晚，使血钙升高；生长激素能够动员周围脂肪分解，参与结石的形成；生长激素能够使血铜升高，铜离子与胆汁中胆红素、粘糖蛋白等结合而形成沉淀物。
The serum levels of growth hormone and insulin in 41 patients with bile duct stones and 31 normal controls were measured by radioimmunoassay. The results showed that the serum levels of growth hormone in patients were significantly higher than those in the control group (P <0.001) Based on this finding, the authors speculated that the formation of biliary pigment stones may be related to the rise of growth hormone and its internal mechanism may be: growth hormone can stimulate parathyroid Late, so that elevated blood calcium; growth hormone mobilizes the surrounding fat decomposition, involved in the formation of stones; growth hormone can increase blood copper, copper and bilirubin, mucins and other binding to form a precipitate.