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2型糖尿病是一种代谢相关的疾病,随着我国老龄化的加速,其患病率不断提升。Brevinin-2Gub是一种具有抗菌作用的阳离子多肽,具有促胰岛素释放作用,在治疗2型糖尿病中极具潜力,AMPK作为细胞的代谢感受器,极有可能成为治疗2型糖尿病的新药理学靶点。本研究整理了AMPK作为治疗糖尿病潜在靶点的最新代谢相关进展,研究Brevinin-2GUb对AMPK信号途径的影响将为其临床应用提供参考。
Type 2 diabetes is a metabolic-related disease, with the accelerated aging of our country, its prevalence is rising. Brevinin-2Gub is an antimicrobial cationic polypeptide with insulinotropic activity. It has great potential in the treatment of type 2 diabetes. As a metabolic sensor of cell, Brevinin-2Gub is likely to become a new pharmacological target for the treatment of type 2 diabetes. In this study, we reviewed the recent advances in the metabolism of AMPK as a potential target for the treatment of diabetes. To investigate the effect of Brevinin-2GUb on AMPK signaling pathway will provide a reference for its clinical application.