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通过颗粒粒径和粒谱对悬浮剂贮存物理稳定性影响研究 ,明确了悬浮剂剂型加工中研磨时间与制剂悬浮颗粒粒径和粒谱分布的关系。结果表明 ,在选定了适当助剂、确定了加工工艺的条件下 ,通过调整研磨时间、降低悬浮颗粒粒径和粒谱分布 ,可以改善悬浮体系的物理稳定性。另外 ,由于研磨时间的延长、粒径变小所带来的悬浮体系粘度的增加 ,对制剂物理稳定性也是非常有利的。
Through the study on the influence of particle size and particle size on the physical stability of suspending agent storage, the relationship between the grinding time and the particle size distribution and particle size distribution of the suspending agent dosage form was clarified. The results show that the physical stability of the suspension system can be improved by adjusting the milling time, reducing the particle size and particle size distribution of suspended particles under the condition of selecting the appropriate additives and determining the processing technology. In addition, due to the prolongation of the milling time, the increase of the viscosity of the suspension system due to the smaller particle size is also very advantageous for the physical stability of the preparation.