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本文主要探讨生物膜在慢性创面中的形成过程、耐药机制、基本结构和形态学等背景.详细讨论了慢性创面愈合过程中生物膜的特点,以及生物膜对创面慢性愈合过程的影响.使用标准敏感性试验(最小抑菌浓度,简称MICs)来确定慢性创面适宜的治疗方案或开发新的治疗方法所面临的困难,并推荐了针对生物膜的可替代的检测方法.并描述了当前和未来潜在的用于治疗含有生物膜的慢性创面的治疗方案,包括毒力减毒、益生菌疗法、免疫反应抑制和完全清创结合抗菌敷料的应用等.“,”Background is provided on biofilms, including their formation, drug resistance mechanisms, general structure, and morphology within the context of chronic wounds. The features of biofilms in chronic are discussed in detail, and the effect of biofilm on the process of chronic wounds healing as well. Difficulties associated with the use of standard susceptibility tests (minimum inhibitory concentrations, MICS) to determine appropriate treatment regimens, or develop new treatments for use, chronic wounds are discussed, with alternate test methods specific to biofilms being recommended. Current and future therapies for treatments of biofilm-containing chronic wounds, including virulence attenuation, probiotic therapy, immune response suppression, and aggressive debridement combined with antimicrobial dressings are described.