论文部分内容阅读
目的:探讨凋亡相关蛋白Clusterin、p27和Survivin在前列腺癌组织中的表达及临床意义。方法:应用免疫组织化学方法检测68例前列腺癌组织和47例前列腺增生组织Clusterin、p27和Survivin蛋白的表达。结果:前列腺癌组织Clusterin、p27和Survivin蛋白的阳性表达率分别为75.0%(51/68)、72.1%(49/68)和67.6%(46/68);前列腺增生组织Clusterin、p27和Survivin蛋白的阳性表达率分别为25.5%(12/47)、19.1%(9/47)和23.4%(11/47)。Clusterin、p27和Survivin蛋白阳性表达率在前列腺癌组织和前列腺增生组织中差异有统计学意义,P<0.01。Clusterin、p27和Survivin蛋白表达与前列腺癌病理分级、临床分期和转移情况具有相关性,P<0.05。前列腺癌组织Survivin与Clusterin、Sur-vivin与p27的表达呈正相关,P<0.01。结论:联合检测Clusterin、p27和Survivin蛋白有助于对进展性前列腺癌细胞的侵袭力作出正确评价,以指导临床治疗。
Objective: To investigate the expression and clinical significance of apoptosis related proteins Clusterin, p27 and Survivin in prostate cancer. Methods: The expressions of Clusterin, p27 and Survivin protein in 68 cases of prostate cancer and 47 cases of benign prostatic hyperplasia were detected by immunohistochemistry. Results: The positive rates of Clusterin, p27 and Survivin in prostate cancer tissues were 75.0% (51/68), 72.1% (49/68) and 67.6% (46/68), respectively. The positive rates of Clusterin, p27 and Survivin in benign prostatic hyperplasia The positive rates were 25.5% (12/47), 19.1% (9/47) and 23.4% (11/47), respectively. The positive rates of Clusterin, p27 and Survivin in prostate cancer and benign prostatic hyperplasia were significantly different (P <0.01). The expressions of Clusterin, p27 and Survivin were correlated with pathological grade, clinical stage and metastasis of prostate cancer (P <0.05). There was a positive correlation between Survivin and Clusterin, Survivin and p27 in prostate cancer (P <0.01). Conclusion: The combined detection of Clusterin, p27 and Survivin proteins can help to evaluate the invasiveness of prostate cancer cells in order to guide the clinical treatment.