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目的评价沙利度胺对糜烂型口腔扁平苔藓的疗效和不良反应。方法选择本院口腔科门诊确诊的糜烂型口腔扁平苔藓70例,用随机数字表法分为两组,治疗组予沙利度胺100mg/d服用,对照组予雷公藤多苷60mg/d服用,治疗8周后比较两组患者的临床疗效和不良反应。结果治疗8周后,治疗组有效率为94.12%,对照组为72.73%,两组差异有统计学意义(P<0.05)。治疗组和对照组不良反应发生率分别为8.57%和6.06%,两组差异无统计学意义(P>0.05)。结论沙利度胺是治疗糜烂型口腔扁平苔藓的有效药物。
Objective To evaluate the efficacy and adverse effects of thalidomide on erosive oral lichen planus. Methods Seventy patients with erosive oral lichen planus diagnosed in our department were divided into two groups by random number table. The treatment group was treated with thalidomide 100 mg / d, and the control group with tripterygium glycosides 60 mg / d After 8 weeks of treatment, the clinical efficacy and adverse reactions of the two groups were compared. Results After 8 weeks of treatment, the effective rate was 94.12% in the treatment group and 72.73% in the control group, with significant difference between the two groups (P <0.05). Adverse reactions in treatment group and control group were 8.57% and 6.06%, respectively, with no significant difference between the two groups (P> 0.05). Conclusion Thalidomide is an effective drug for the treatment of erosive oral lichen planus.