妊高征常发生于初产妇,尤其是初交时妊娠及人工授精者发病率更高。同一对夫妇,如第一胎发生妊高征,第二次妊娠时就不患妊高征或即使患妊高征,症状也明显减轻,由此建立了“由第一次妊娠引起的免疫耐受假说”。众所周知,当细菌或病毒感染时T细胞与抗原发生第一次免疫应答后,二次应答记忆性T细胞迅速增殖,产生强烈的免疫反应。 Pregnancy-induced hypertension often occurs in primipara, especially when first-time pregnancy and artificial insemination a higher incidence. The same couple, such as the first fetus with PIH, the second pregnancy without PIH or even with PIH, the symptoms were significantly reduced, thus establishing a “first pregnancy caused by immune tolerance Hypothetical. ” It is well-known that when T cells and antigens are infected for the first time after bacterial or virus infection, the secondary memory T cells rapidly proliferate and produce a strong immune response.