通过放射免疫分析法测定新生儿缺氧缺血性脑病脑脊液中β－内啡肽（β－ＥＰ）和强啡肽１－１３（ＤｙｎＡ１－１３）的含量变化，结果表明，β－ＥＰ在患儿组含量显著升高，ＤｙｎＡ１－１３则明显降低，并与脑损伤程度有关．还发现，β－ＥＰ含量在发病７２ｈ内升高最著，４～７ｄ下降，１０～１５ｄ基本恢复正常，ＤｙｎＡ１－１３含量变化，则呈相反趋势，提示，两种阿片肽可能参与新生儿缺氧缺血性脑病病理生理过程．并为临床判断新生儿缺氧缺血性脑病病情、预后、疗程提供了参考依据． The levels of β-EP and DynA1-13 in cerebrospinal fluid in neonates with hypoxic-ischemic encephalopathy were measured by radioimmunoassay. The results showed that β-EP in patients The content of children increased significantly, DynA1-13 was significantly reduced, and the degree of brain damage. It was also found that the content of β-EP increased most within 72 hours of onset, decreased from 4 to 7 days and returned to normal within 10 to 15 days. The change of DynA1-13 content showed the opposite trend, suggesting that the two opioid peptides may participate in neonatal absence Oxygen Ischemic Encephalopathy Pathophysiology. And provide a reference for judging the condition, prognosis and course of the neonatal hypoxic-ischemic encephalopathy clinically.