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目的探讨脑出血(ICH)老年患者血清人细胞纤维连接蛋白(cFN)的表达水平及其临床意义。方法以2014年3月-2015年12月在本院接受治疗的50例ICH老年患者为观察对象,同时选取50例健康老年人作为对照组。观察两组患者血清cFN、炎症细胞因子水平,比较死亡和未死亡ICH患者血清cFN、炎症细胞因子水平的差异。分析cFN与炎症细胞因子水平的相关性。结果 ICH组患者血清cFN、白介素-6(IL-6)、超敏反应C蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)水平明显高于对照组(P<0.05);死亡的ICH患者其血清cFN、IL-6、hs-CRP和TNF-α水平明显高于未死亡者(均P<0.05);不同NIHSS评分患者的cFN、炎症细胞因子水平由高到低分别为≥15分者、8~14分者和≤7分者(均P<0.05);cFN水平与NIHSS评分、IL-6、hs-CRP和TNF-α水平显著正相关(r=0.420、0.356、0.412、0.398,均P<0.05)。结论 ICH老年患者血清cFN水平较高,且其水平与患者的神经功能缺损程度和细胞因子水平密切相关。
Objective To investigate the expression of serum human fibronectin (cFN) in elderly patients with intracerebral hemorrhage (ICH) and its clinical significance. Methods Fifty elderly patients with ICH who were treated in our hospital from March 2014 to December 2015 were selected as the observation subjects and 50 healthy elderly patients were selected as the control group. Serum levels of cFN and inflammatory cytokines in both groups were observed, and the difference of serum cFN and inflammatory cytokines was compared between the two groups. Correlation between cFN and levels of inflammatory cytokines was analyzed. Results The levels of serum cFN, IL-6, hs-CRP and TNF-α in ICH group were significantly higher than those in control group (P <0.05). The death The levels of cFN, IL-6, hs-CRP and TNF-α in patients with ICH were significantly higher than those without death (all P <0.05). The levels of cFN and inflammatory cytokines in patients with different NIHSS scores from high to low were ≥ 15 points, 8-14 points and ≤7 points (all P <0.05). There was a significant positive correlation between cFN level and NIHSS score, IL-6, hs-CRP and TNF- , 0.398, all P <0.05). Conclusion The level of serum cFN in elderly patients with ICH is high, and its level is closely related to the degree of neurological deficit and the level of cytokines in patients.