论文部分内容阅读
目的 探讨新生儿硬肿症血浆血管性假血友病因子 (vWF)的意义。方法 采用免疫浊度法检测3 9例新生儿硬肿症和 11例正常新生儿血浆vWF水平。结果 硬肿症组血浆vWF明显高于对照组 (P <0 .0 0 5 ) ,轻度硬肿组与对照组比较无显著性差异 (P >0 .0 5 ) ,中、重度硬肿组血浆vWF均明显高于对照组 (P均 <0 .0 5 ) ,且血浆vWF升高与硬肿症程度相一致 ;血浆vWF与血pH呈负相关 (r =- 0 .80 8 P <0 .0 0 1)。结论 中、重度硬肿症体内存在以高凝为主的早期DIC ,血管内皮细胞损伤参与其病理生理过程。
Objective To investigate the significance of vWF in neonates with scleredema. Methods 39 cases of neonatal scleredema and 11 cases of normal neonates were tested for plasma vWF by immunoturbidimetry. Results The vWF in sclerodema group was significantly higher than that in control group (P <0.05). There was no significant difference between mild sclerosis group and control group (P> 0.05), moderate and severe sclerosis group The vWF in plasma was significantly higher than that in control group (all P <0.05), and the vWF in plasma was consistent with the severity of scleredema. Plasma vWF was negatively correlated with blood pH (r = - 0.808 P <0 .0 0 1). Conclusions There are early DICs in the medium and severe cases with hypercoagulability. The injury of vascular endothelial cells is involved in the pathophysiological process.