论文部分内容阅读
目的评价老年高脂血症患者使用他汀类药物降脂治疗的安全性。方法监测2011年12月至2012年12月我院老年高脂血症患者使用他汀类药物的不良反应发生情况,并研究用药剂量与不良反应发生的关系。结果共收集到2 273例使用他汀类药物患者的病历资料,其中老年高脂血症患者997例,发生他汀类用药不良反应者103例,发生率为10.3%;不良反应累及多个系统,神经肌肉系统和消化系统发生较多,用药剂量≥40 mg时,不良反应增加。结论他汀类药物不良反应可累及多个系统,但总体较轻,不影响治疗,用药较为安全。
Objective To evaluate the safety of lipid-lowering treatment with statins in elderly patients with hyperlipidemia. Methods The incidence of adverse reactions to statins in elder patients with hyperlipidemia in our hospital from December 2011 to December 2012 was monitored and the relationship between dosage and adverse reactions was studied. Results A total of 2 273 patients with statins were enrolled in the study. Among them, 997 were elderly patients with hyperlipidemia and 103 were statin adverse reactions. The incidence rate was 10.3%. Adverse reactions involved multiple systems and nerves Muscle system and digestive system occurred more, medication dose ≥ 40 mg, adverse reactions increased. Conclusions Adverse reactions to statins can affect multiple systems, but overall are mild and do not affect the treatment. The medication is safer.