目的：研究鹿茸总多肽（ＶＡＴＰ）和鹿茸多肽ＶＡＰＡ，ＶＡＰＢ和ＶＡＰＣ对细胞增殖的影响．方法：分离家兔和人胚软骨细胞及鸡胚头盖骨细胞，体外加入ＶＡＴＰ，ＶＡＰＡ，ＶＡＰＢ和ＶＡＰＣ，观察其对［３Ｈ］ＴｄＲ参入细胞ＤＮＡ合成的影响．整体观察了ＶＡＴＰ促进实验性大鼠桡骨骨折愈合作用．结果：ＶＡＴＰ５０－２００ｍｇ·Ｌ－１和ＶＡＰＢ１２５－５０ｍｇ·Ｌ－１促进软骨及成骨样细胞有丝分裂，ＶＡＰＡ作用较弱，ＶＡＰＣ无效．ＶＡＴＰ１０－２０ｍｇ·ｋｇ－１加速了大鼠桡骨骨折的愈合．结论：ＶＡＴＰ加速骨折愈合的作用与其促进软骨和成骨样细胞的增殖有关 Objective: To study the effect of antler polypeptide (VATP) and antler polypeptide VAPA, VAPB and VAPC on cell proliferation. METHODS: Rabbits and human embryonic chondrocytes and chicken embryonic cranial bone cells were isolated and VATP, VAP-A, VAP-B and VAPC were added in vitro to observe their effect on [3H]TdR incorporation into DNA synthesis. The overall observation of the role of VATP in the healing of tibial fractures in experimental rats. Results: VATP50-200mg·L-1 and VAPB125-50mg·L-1 promoted the mitosis of cartilage and osteoblast-like cells. The effect of VAPA was weak, and VAPC was ineffective. VATP10-20mg·kg-1 accelerated the healing of rat tibial fractures. Conclusion: The role of VATP in accelerating fracture healing is related to its promotion of proliferation of cartilage and osteoblast-like cells.