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目的：探讨血液ＡＦＰｍＲＮＡ在复发性肝癌及伴有肝外远处器官转移的原发性肝癌中的表达及意义。方法：应用巢式ＲＴ－ＰＣＲ检测４０例复发性肝癌及伴有肝外远处器官转移的原发性肝癌血液ＡＦＰｍＲＮＡ。结果：２１例伴有肝外远处器官转移的原发性肝癌血液ＡＦＰｍＲＮＡ均表达阳性（１００％），１９例复发性肝癌患者中有７例血液ＡＦＰｍＲＮＡ表达阳性（３６．８％），两组比较差异有显著性意义（Ｐ＜０．０１）。结论：血液ＡＦＰｍＲＮＡ有希望成为判断肝癌复发或预测肝癌远处器官转移的客观性指标之一。
Objective: To investigate the expression and significance of blood AFPmRNA in primary liver cancer with recurrent hepatocellular carcinoma and extrahepatic distant organ metastasis. METHODS: Nested RT-PCR was used to detect AFP mRNA in 40 cases of recurrent hepatocellular carcinoma and primary liver cancer with extrahepatic distant organ metastasis. RESULTS: The expression of AFP mRNA was positive in 100 cases of primary hepatocellular carcinoma with extrahepatic distant organ metastasis, and 7 of 19 cases of recurrent hepatocellular carcinoma had positive AFP mRNA expression (36.8%). The difference was significant (P<0.01). Conclusions: Blood AFP mRNA is expected to be one of the objective indicators for judging the recurrence of HCC or predicting distant metastasis of HCC.