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我国SARS冠状病毒灭活疫苗的研制工作又迈过一道“门槛”:灵长类动物感染模型已经取得突破性进展,两项灭活疫苗研究已完成实验室制备,免疫灵长类动物实验进展比较顺利。 实验表明,用SARS冠状病毒灭活疫苗免疫的猴子,在注射后只出现体温轻微升高,未见其它临床、病理、生化指标异常,也未检出灭活疫苗的病毒活性。各项指标表明,此灭活疫苗是安全的。同时,免疫后的猴子体内产生厂SARS冠
The SARS Coronavirus Inactivated Vaccine in China has stepped into another “threshold”: a breakthrough has been made in primate infection models. Two inactivated vaccine studies have been completed in laboratory and the progress of immunization primate experiments has been compared smoothly. Experiments show that the SARS coronavirus inactivated vaccine immunized monkeys, only a slight increase in body temperature after injection, no other clinical, pathological and biochemical abnormalities, nor inactivated vaccine inactivation was detected. The indicators show that this inactivated vaccine is safe. Meanwhile, the immunized monkeys produced plant-derived SARS crowns in vivo