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目的:本研究探讨当归芍药散水提取物对秋水仙碱诱导的被动回避学习障碍的影响及脑中超氧化物歧化酶含量的变化。方法:以电痛刺激实验及大鼠自发运动量仪测定大鼠被动回避学习、痛阈值及运动量改变。结果:当归芍药散水提取物(0.1-1.0g/kg)可明显改善秋水仙碱诱导大鼠之被动回避学习获得障碍,并增加秋水仙碱诱发的大鼠脑中超氧化物歧化酶的含量。但对痛阈值和运动量并无影响。结论:当归芍药散水提取物对秋水仙碱诱导的被动回避学习获得障碍有改善作用,其作用可能与改善秋水仙碱造成的细胞损伤或增加脑中超氧化物歧化酶含量有关,而非与镇痛和镇静有关。
OBJECTIVE: This study was to investigate the effects of Danggui Shaoyao water extract on colchicine-induced passive avoidance learning disorders and changes in brain superoxide dismutase (SOD) content. METHODS: Rats’ passive avoidance learning, pain threshold and exercise volume were measured by electrotonic stimulation test and spontaneous exerciser test. RESULTS: Danggui Shaoyao water extract (0.1-1.0 g/kg) could significantly improve the passive avoidance learning of rats induced by colchicine, and increase the content of superoxide dismutase in the brain of rats induced by colchicine. However, there is no effect on the pain threshold and the amount of exercise. Conclusion: Danggui Shaoyao water extract can improve the passive avoidance learning induced by colchicine, which may be related to the improvement of colchicine-induced cell injury or increase of SOD content in the brain, rather than analgesia. Related to calmness.