术中和围手术期预防性应用抗生素早巳肯定,尤其局部用抗生素伤口感染率显著降低,与注射给药相似。但局部给抗生素机理不清,可能有:(1)局部高浓度抗生素的直接作用;(2)局部给抗生素血清浓度高于最低抑制浓度(MIC),机体吸收后再分布至伤口;或两者皆有。作者检测给头孢唑啉(Cefazolin)后血清和伤口渗液中药物浓度,观察伤口药物浓度和全身 Intravenous and perioperative prophylactic antibiotics have long been affirmed, especially in topical antibiotic wound infection was significantly reduced, similar to the injection. However, the local antibiotic mechanism is not clear, there may be: (1) the direct effect of local high concentrations of antibiotics; (2) topically antibiotic serum concentrations higher than the minimum inhibitory concentration (MIC), the body absorbed and then distributed to the wound; or both All have. The authors tested the cefazolin (Cefazolin) serum and wound exudate drug concentration, the wound drug concentration and the body