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目的评价肿瘤特异性生长因子（ＴＳＧＦ）诊断肿瘤的价值及其临床意义。方法血清中ＴＳＧＦ与显色剂呈显色反应，测其吸光度，查标准曲线，求出ＴＳＧＦ含量，并设健康组、肺感染组和慢性肝炎组作为对照组。结果８３例肿瘤病人血清ＴＳＧＦ含量（７１．１２±１１．０３ｕ／ｍｌ）显著高于３０例健康对照组（Ｐ＜０．００１）、３０例肺感染组（Ｐ＜０．００１）和３０例慢性肝炎组（Ｐ＜０．００１）。ＴＳＧＦ在肺癌、消化系统和泌尿生殖系肿瘤中的阳性率显著高于ＣＥＡ阳性率（Ｐｔ＞２）。２２例化疗有效者血清ＴＳＧＦ含量较化疗前显著降低（Ｐ＜０．００１），８例恶化者则显著升高（Ｐ＜０．００１）。检测肿瘤血清ＴＳＧＦ的敏感性、特异性和准确性分别为９１．５７％、９６．６０％和９２．０４％。结论ＴＳＧＦ是一种新的敏感性和特异性较高的广谱肿瘤标志物，对肿瘤的辅助诊断、疗效评价和预示肿瘤复发具有重要临床意义。
Objective To evaluate the value and clinical significance of tumor specific growth factor (TSGF) in the diagnosis of tumors. Methods The serum TSGF reacted with the coloring agent to develop a color reaction. The absorbance was measured, and the standard curve was examined to determine the content of TSGF. The healthy group, lung infection group and chronic hepatitis group were set as the control group. Results Serum TSGF levels (71.12±11.03u/ml) were significantly higher in 83 tumor patients than in 30 healthy controls (P<0.001), 30 pulmonary infections (P<0.001), and 30 patients. Chronic hepatitis group (P<0.001). The positive rate of TSGF in lung, digestive and urogenital tumors was significantly higher than that of CEA (Pt>2). Serum TSGF levels in 22 patients with effective chemotherapy were significantly lower than those before chemotherapy (P<0.001), and those in 8 patients with worsening were significantly higher (P<0.001). The sensitivity, specificity and accuracy of detecting serum TSGF were 91.57%, 96.60% and 92.04%, respectively. Conclusions TSGF is a new type of broad-spectrum tumor marker with high sensitivity and specificity. It has important clinical significance in the diagnosis of tumors, evaluation of therapeutic effect, and prediction of tumor recurrence.