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目的探讨碱性成纤维细胞生长因子(bFGF)与缺氧缺血性脑损伤(HIBD)后神经细胞内源性修复机制的相关性。方法 128只SD大鼠随机均分为假手术(A)组、单纯缺氧(B)组、单纯缺血(C)组和缺氧缺血(D)组。建立HIBD模型,免疫组化检测溴化脱氧核糖尿嘧啶(BrdU)阳性细胞表达,RT-PCR检测海马bFGF mRNA表达。结果与其余各组比较,D组BrdU阳性细胞数及bFGF mRNA表达于HIBD后7、14d明显增加(P<0.05)。结论 HIBD后海马齿状回存在神经细胞再生,bFGF可能参与HIBD后神经细胞内源性修复机制。
Objective To investigate the correlation between basic fibroblast growth factor (bFGF) and the intrinsic repair mechanism of nerve cells after hypoxic-ischemic brain damage (HIBD). Methods 128 Sprague - Dawley rats were randomly divided into three groups: sham group (A), simple hypoxia group (B), simple ischemia group (C) and hypoxic ischemic group (D). The HIBD model was established. The expression of BrdU positive cells was detected by immunohistochemistry. The bFGF mRNA expression was detected by RT-PCR. Results Compared with the other groups, the number of BrdU positive cells and the expression of bFGF mRNA in group D were significantly increased at 7 and 14 days after HIBD (P <0.05). Conclusion The hippocampal dentate gyrus after HIBD regenerates nerve cells, and bFGF may participate in the intrinsic repair mechanism of neurons after HIBD.