论文部分内容阅读
肝炎病毒感染与遗传因素乙型肝炎表面抗原(HBsAg,即AuAg)发现者Blumberg曾推测该抗原为具有遗传性血清蛋白多态性性质的病原体,依同它的宿主血清蛋白遗传特性相合是否一致而决定宿主感染、慢性携带或产生抗体。他通过家系调查,认为带有Au~1纯合子的人在感染乙型肝炎病毒(HBV)后容易成为携带病毒的常染色体隐性遗传。这就是所谓Icron学说,简括说明如下: 基因型 AuAg持续性表现型 Au~1/Au~1 (+) Au~[1] Au~1/Au (-) Au~[0] Au/Au (-) Au~[0] 于是,提出热带和温带地区HBsAg检出率的不同可由热带地区Au~1携带者众多来解释。Szmuness进行95例HBsAg先证者家系基因分离分析(genetic segregationanalysis)结果,也支持这一学说。
Hepatitis V infection and genetic factors Discovered by Blumberg Discovered Hepatitis B Surface Antigen (HBsAg, AuAg) Discovered that the antigen is a genetic pathogen with genetic polymorphism of serum protein, consistent with its host serum protein genetic characteristics coincide and Host infection, chronic carrier or produce antibodies. Through pedigree investigation, he believes that people with Au ~ 1 homozygotes are susceptible to virus-carrying autosomal recessive inheritance after being infected with Hepatitis B virus (HBV). This is the so-called Icron theory, which is briefly described as follows: genotype AuAg persistent phenotype Au ~ 1 / Au ~ 1 (+) Au ~ [1] Au ~ 1 / Au (-) Au ~ [0] Au / Au ) Au ~ [0] Therefore, it is proposed that the difference between the detection rates of HBsAg in tropical and temperate regions can be explained by the large number of Au ~ 1 carriers in tropical regions. Szmuness carried out 95 cases of genetic segregation analysis of HBsAg probands (genetic segregationanalysis) results, also support this theory.