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目的了解α干扰素(IFN-α)在移植前使用对慢性粒细胞白血病(CML)患者非亲缘异基因骨髓移植(URD-BMT)预后的影响。方法分析总结行URD-BMT的CML第1次慢性期(CP1)患者53例,其中BMT前未用IFN-α治疗组23例,用IFN-α治疗组30例;其中疗程≤12个月22例,>12个月8例。采用单因素分析和Cox比例风险模型分析移植前使用IFN-α对CML患者URD-BMT后植入效果、急性移植物抗宿主病(GVHD)发生及患者5年存活率的影响。结果经Cox模型多元回归分析,患者年龄、性别、确诊至URD-BMT的时间、停IFN-α距URD-BMT时间对生存率无影响;各组的总生存率、无病生存率、非复发死亡率、植活率、复发率、植入失败率、急性GVHD和慢性GVHD发生率差异均无统计学意义均(P>0.05)。结论本文资料所列条件下,移植前使用IFN-α不会对URD-BMT产生不利影响。
Objective To investigate the effect of IFN-α before transplantation on the prognosis of unrelated allogeneic bone marrow transplantation (CML) in patients with unrelated allogeneic bone marrow transplantation (URD-BMT). Methods Fifty-three patients with CML first chronic phase (CP1) who underwent URD-BMT were analyzed. Among them, 23 cases were treated with IFN-α before BMT and 30 cases were treated with IFN-α. Among them, the course of treatment was ≤12 months Cases,> 12 months and 8 cases. Univariate analysis and Cox proportional hazard model were used to analyze the effect of IFN-α before transplantation on the implantation effect, the incidence of acute graft-versus-graft disease (GVHD) and the 5-year survival rate of patients with CML after URD-BMT. Results The multivariate regression analysis of Cox model, patient age, gender, the time of diagnosis to URD-BMT, no effect of IFN-α from URD-BMT on survival rate; the overall survival, disease-free survival, Mortality, survival rate, recurrence rate, implantation failure rate, acute GVHD and chronic GVHD were not significantly different (P> 0.05). Conclusions The use of IFN-α prior to transplantation does not adversely affect URD-BMT under the conditions listed in this paper.