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目的:探讨中药生精散对男性不育患者精子DNA损伤的修复作用。方法:选择56例少、弱精子症的不育患者,随机分为中药组和对照组,各28例。中药组服用生精散,对照组服用维生素C及维生素E,治疗1～3个月后复查精液常规及精子DNA碎片指数(DFI),观察两组行IVF-ET周期中获卵数、MⅡ卵子数、受精数、卵裂数、可用胚胎数、种植率、临床妊娠率及流产率。结果:两组治疗前精子密度、活力、活率及DFI值均无显著性差异(P>0.05),治疗后中药组精子活力、活率与治疗前及对照组比较显著提高(P<0.05),DFI值较治疗前及对照组明显下降(P<0.05)。中药组胚胎种植率及临床妊娠率(31.3%vs 15.3%,46.4%vs 21.4%)明显高于对照组(P<0.05),中药组流产率较对照组低(15.4%vs 33.3%)。结论:中药生精散能够明显降低不育患者精子DFI值,提示其能够通过对损伤精子DNA的修复作用,提高精子质量,改善IVF-ET治疗患者的妊娠结局。
Objective: To investigate the effect of Shengjing Powder on repair of sperm DNA damage in male infertility patients. Methods: Fifty-six infertile patients with less asthenospermia were randomly divided into TCM group and control group, with 28 cases in each group. The Chinese medicine group took Shengjing Powder and the control group took vitamin C and vitamin E. The routine and sperm DNA fragmentation index (DFI) were examined after 1 to 3 months of treatment. The number of oocytes retrieved in IVF-ET cycle, Number, number of fertilization, number of cleavage, number of available embryos, implantation rate, clinical pregnancy rate and abortion rate. Results: There was no significant difference in sperm density, viability, viability and DFI between the two groups before treatment (P> 0.05). After treatment, the sperm motility and viability of the Chinese medicine group were significantly increased compared with those before treatment and the control group (P <0.05) , DFI value was significantly lower than before treatment and control group (P <0.05). The implantation rate and clinical pregnancy rate of Chinese medicine group (31.3% vs 15.3%, 46.4% vs 21.4%) were significantly higher than those of control group (P <0.05). The abortion rate of Chinese medicine group was lower than that of control group (15.4% vs 33.3%). Conclusion: Shengjing Powder can significantly reduce the sperm DFI value of infertile patients, suggesting that it can improve the sperm quality and improve the pregnancy outcome of patients treated with IVF-ET through the repair of damaged sperm DNA.