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硝酸酯类血管扩张剂是最老的抗心绞痛药物，目前已广泛用于治疗冠心病（CHD）和充血性心力衰竭（CHF）。近20年来，硝酸酯耐药越来越受到临床重视。随着基础医学研究的进步，对其耐药机制有了更多的了解，避免、防止耐药的研究也取得了重大进展。1研究现状1888年Stewart首先注
Nitric ester vasodilators are the oldest anti-anginal drugs currently used in the treatment of coronary heart disease (CHD) and congestive heart failure (CHF). In the past 20 years, nitrate resistance has gained more and more clinical attention. With the progress of basic medical research, more understanding of its resistance mechanism has been made, and great progress has been made in the study of avoiding and preventing drug resistance. 1 research status 1888 Stewart first note