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目的探讨激素替代治疗对老年甲状腺功能减退患者认知功能的作用。方法 74例甲状腺功能减退的老年患者,均给予甲状腺激素替代治疗,比较治疗前后患者甲状腺激素水平变化以及认知功能改善情况。结果与治疗前相比,治疗后患者的简易智能精神状态量表(MMSE)评分及游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)明显升高,但促甲状腺激素(TSH)明显降低,差异均有统计学意义(P<0.05)。结论老年甲状腺功能减退采用激素替代治疗,可显著改善患者的临床症状,提高其认知功能,值得临床借鉴和积极推广。
Objective To investigate the effect of hormone replacement therapy on cognitive function in elderly patients with hypothyroidism. Methods Thirty-four elderly patients with hypothyroidism were given thyroid hormone replacement therapy, and the changes of thyroid hormone levels and cognitive function were compared before and after treatment. Results Compared with those before treatment, MMSE scores, FT3 and FT4 in patients after treatment were significantly higher than those before treatment, but thyroid stimulating hormone (TSH ) Was significantly lower, the difference was statistically significant (P <0.05). Conclusion Hypothyroidism in elderly patients with hormone replacement therapy can significantly improve the patient’s clinical symptoms and improve their cognitive function, it is worth learning from and actively promote.