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病例介绍一位38岁的妇女,有间歇性疲乏、关节痛、口腔溃疡、胸膜炎和对光敏感的面疹等10年病史,4年前入院。BP140/80,体检发现颧疹,外周淋巴结和脾肿大。血清学检查:抗DNA滴度24mg/ml(正常<2.5mg/ml),血清总补体(CH 50)58u(正常>50u),C_30.32mg/ml(正常0.87～2.2)。尿:蛋白(+++),血(+),WBC10～15/HP,RBC 2～4/HP,24小时尿蛋白1.3g。血清肌酐0.8mg/dl。病者开始用强的松40mg/日治疗,但血清补体值仍低。血压升至180/110,开始用双氢克尿噻治疗,她对强的松耐受性差,出现情绪改变和柯兴氏征。强的
Case Presentation A 38-year-old woman with a 10-year history of intermittent fatigue, joint pain, mouth ulcers, pleurisy and light-sensitive rash was admitted 4 years ago. BP140 / 80, physical examination found that zygomatic rash, peripheral lymph nodes and splenomegaly. Serological tests: anti-DNA titer of 24mg / ml (normal <2.5mg / ml), total serum complement (CH50) 58u (normal> 50u), C_30.32mg / ml (normal 0.87 ~ 2.2). Urine: protein (+++), blood (+), WBC10-15 / HP, RBC 2-4 / HP, urinary protein in 24 hours 1.3g. Serum creatinine 0.8mg / dl. Patients began to use prednisone 40mg / day treatment, but serum complement values are still low. Blood pressure rose to 180/110, started with hydrochlorothiazide therapy, her poor tolerance to prednisone, mood changes and Cushing’s sign. Strong