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目的:观察注射用阿糖腺苷联合喜炎平注射液治疗小儿病毒性脑炎的临床疗效。方法:选取本院收治的81例病毒性脑炎患儿为研究对象,根据入院先后顺序随机分为对照组与观察组。对照组给予注射用阿糖腺苷治疗,观察组给予注射用阿糖腺苷联合喜炎平注射液治疗。观察2组临床疗效,比较2组症状消失时间、不良反应发生情况以及治疗前后血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的变化。结果:总有效率观察组为95.12%,高于对照组的80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组的发热、头痛、呕吐、惊厥及意识障碍等症状的消失时间均短于对照组(P<0.05)。治疗前,2组血清IL-1、IL-6及TNF-α水平比较,差异均无统计学意义(P>0.05)。治疗后,2组IL-1、IL-6及TNF-α水平均较治疗前下降(P<0.05),观察组3项指标水平均低于对照组(P<0.05)。结论:注射用阿糖腺苷联合喜炎平注射液治疗小儿病毒性脑炎临床疗效显著,可有效缩短患儿发热、头痛、惊厥及意识障碍等临床症状的消失时间,同时降低患儿的IL-1、IL-6及TNF-α水平。
Objective: To observe the clinical efficacy of injection of adenosine arabinoside and xiyanping injection in the treatment of pediatric viral encephalitis. Methods: A total of 81 children with viral encephalitis admitted to our hospital were selected as study subjects and randomly divided into control group and observation group according to the order of admission. The control group was treated with injection of adenosine arabinoside and the observation group was treated with injection of adenosine arabinoside and xiyanping injection. The clinical curative effect of the two groups were observed. The symptom disappearance time, the incidence of adverse reactions and the levels of serum interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α -α) level changes. Results: The total effective rate in the observation group was 95.12%, which was higher than that in the control group (80.00%). There was significant difference between the two groups (P <0.05). After treatment, the disappearance of fever, headache, vomiting, convulsions and disturbance of consciousness in the observation group were shorter than those in the control group (P <0.05). Before treatment, there was no significant difference in serum IL-1, IL-6 and TNF-α levels between the two groups (P> 0.05). After treatment, the levels of IL-1, IL-6 and TNF-α in the two groups were significantly lower than those before treatment (P <0.05). The three indexes in the observation group were lower than those in the control group (P <0.05). Conclusion: The clinical efficacy of injection of adenosine arabinoside and xiyanping injection in treating children with viral encephalitis is significant, which can effectively shorten the disappearance time of clinical symptoms such as fever, headache, convulsion and disturbance of consciousness, and reduce the IL -1, IL-6 and TNF-α levels.