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目的:评价金龙固本补肺健脾合剂治疗支气管哮喘缓解期的临床疗效及对免疫功能的影响。方法:将239例支气管哮喘缓解期患者随机分为对照组和试验组,试验组连续口服金龙固本补肺健脾合剂100ml,日二次口服,4个月,对照组不予药物干预,观察随访1年时疾病复发率,外周血嗜酸性细胞(EOS)计数,血CD4、CD8,血Ig A、Ig M、Ig G、Ig E水平等指标。结果:疾病复发率:试验组总有效率为98.29%,对照组总有效率为77.27%,两组间比较差异有显著统计学意义(P<0.01);在随访1年时,试验组与对照组血CD4、CD8水平差异无统计学意义;试验组外周血嗜酸性粒细胞计数较治疗前明显下降,而对照组较治疗前明显升高;试验组血Ig A、Ig M明显高于治疗前,血Ig G与治疗前比较均无明显变化,试验组血Ig E明显低于治疗前,而对照组明显高于治疗前,试验组与对照组血Ig A、Ig M、Ig G差异无统计学意义,试验组与对照组血Ig E差异有统计学意义。结论:金龙固本补肺健脾合剂能降低哮喘患者外周血嗜酸性粒细胞水平,提高血Ig A、Ig M水平,降低血Ig E,明显减少支气管哮喘发作次数,预防支气管哮喘急性发作,为哮喘缓解期治疗提供了新选择。
Objective: To evaluate the clinical efficacy of Jinlong Guben Bufei Jianpi Mixture in the treatment of bronchial asthma and its effect on immune function. Methods: 239 cases of bronchial asthma remission patients were randomly divided into control group and experimental group. The experimental group was given 100ml of Jinlong Guben Bufei Jianpi Mixture continuously, orally twice daily for 4 months. The control group received no drug intervention. Follow-up of 1 year disease recurrence rate, peripheral blood eosinophils (EOS) count, blood CD4, CD8, blood IgA, IgM, IgG, IgE levels and other indicators. Results: The recurrence rate was 98.29% in the trial group and 77.27% in the control group, with significant difference between the two groups (P <0.01). At the one year follow-up, the test group and the control group The blood levels of CD4 and CD8 were not significantly different between the two groups. The number of peripheral blood eosinophils in the experimental group was significantly lower than that before treatment, while the level in the control group was significantly higher than that before treatment. The levels of IgA and IgM in the experimental group were significantly higher than those before treatment , Blood Ig G and no significant change before treatment, the test group of blood Ig E was significantly lower than before treatment, while the control group was significantly higher than before treatment, test group and control group, blood Ig A, Ig M, Ig G no statistical difference Significance of the study, test group and control group, blood IgE difference was statistically significant. Conclusion: Jinlong Guben Bufei Jianpi Mixture can reduce the level of eosinophils in peripheral blood of patients with asthma, increase the levels of Ig A and Ig M in blood, decrease the blood Ig E, significantly reduce the number of bronchial asthma attacks, and prevent the acute attack of bronchial asthma. Asthma remission treatment provides a new choice.