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目的研究多肽N-乙酰氨基半乳糖转移酶10(pp-GalNac-T10)在食管鳞状细胞癌(ESCC)组织中的表达水平及其与临床指标的关系。方法对120例ESCC患者的组织芯片,采用免疫组织化学法检测pp-GalNac-T10在ESCC中的表达,并分析其表达与临床病理参数之间的关系。结果 ESCC组织中pp-GalNac-T10表达与癌旁组织类似,但pp-GalNac-T10表达的阳性率与ESCC淋巴结受累、TNM分期情况相关,pp-GalNac-T10在发生转移患者的癌组织表达强度明显高于未发生转移患者的癌组织。结论 pp-GalNac-T10的表达与ESCC的淋巴结转移有关。
Objective To study the expression of pp-GalNac-T10 in esophageal squamous cell carcinoma (ESCC) and its relationship with clinical parameters. Methods The expression of pp-GalNac-T10 in ESCC was detected by immunohistochemistry in 120 ESCC tissue samples. The relationship between the expression and clinicopathological parameters was analyzed. Results The expression of pp-GalNac-T10 in ESCC tissues was similar to that in paracancerous tissues, but the positive rate of pp-GalNac-T10 expression was related to lymph node involvement and TNM staging in ESCC. The expression of pp-GalNac-T10 in cancer tissues with metastasis Significantly higher than in patients without metastasis of cancer tissue. Conclusion The expression of pp-GalNac-T10 is related to lymph node metastasis in ESCC.