自噬是细胞内物质代谢的重要途径,是真核细胞中广泛存在着的降解再循环系统的重要组成部分,其可作为神经细胞的保护机制,也可作为神经细胞死亡方式之一。Beclin 1是最近发现参与细胞自噬调控的蛋白之一,参与自噬体形成的启动过程,与某些疾病如肿瘤、惊厥性脑损伤的发生等密切相关。惊厥是儿科常见的急重症,反复的惊厥性损伤不但影响患儿的智力发育,而且严重惊厥可引起永久性脑损伤,甚至留有后遗症,给患儿及家庭带来沉重打击。最近研究表明,反复惊厥后海马Beclin1表达迅速上调,自噬激活与惊厥导致的脑损伤密切相关。Beclin1作为重要的细胞自噬基因,为惊厥性脑损伤的防治提供了的治疗方向 Autophagy is an important pathway for the metabolism of intracellular substances. It is an important part of the degradation and recirculation system that exists widely in eukaryotic cells. It can be used as a protective mechanism of nerve cells and also as a way of nerve cell death. Beclin 1, one of the recently discovered proteins involved in the regulation of autophagy, is involved in the initiation of autophagosome formation and is closely related to certain diseases such as tumors and the development of convulsive brain injury. Convulsions are common in pediatric critical illness, recurrent seizures not only affect the children's intellectual development, and severe seizures can cause permanent brain damage, and even left sequelae, to bring a heavy blow to children and families. Recent studies have shown that Beclin1 expression in hippocampus rapidly recurred after repeated convulsions, and autophagy activation was closely related to brain injury caused by convulsion. Beclin1, as an Important Cell Autophagy Gene, Provides the Treatment Direction for Prevention and Treatment of Convulsive Brain Injury