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目的:观察胃安宁颗粒对SGC-7901荷瘤裸鼠血管VEGF、Ki-67表达的影响。方法:将裸鼠皮下接种胃癌SGC-7901细胞后随机分为对照组、阳性药组及胃安宁颗粒大、中、小剂量组,用药后分别计算瘤重系数,并将肿瘤组织进行免疫组织化学染色,检测VEGF、Ki-67表达的情况。结果:胃安宁颗粒大、中剂量均能明显降低荷瘤裸鼠瘤重和瘤重系数(P<0.05～0.001),免疫组织化学染色显示,应用胃安宁颗粒后肿瘤组织VEGF、Ki-67的表达有所下降。结论:胃安宁颗粒可能通过抑制VEGF、Ki-67的表达起到抑制肿瘤血管生成的作用,从而达到抗肿瘤的目的。
Objective: To observe the effect of Weianning granule on the expression of VEGF and Ki-67 in vascular of SGC-7901 tumor-bearing nude mice. Methods: The nude mice were inoculated subcutaneously into SGC-7901 cells and then randomly divided into control group, positive drug group, and Wei’an Granules group. The tumor weight coefficient was calculated and the tumor tissues were immunohistochemically Staining, detection of VEGF, Ki-67 expression. Results: The large dose and middle dose of Weianning Granule could significantly reduce the tumor weight and tumor weight coefficient of tumor-bearing nude mice (P <0.05-0.001). Immunohistochemical staining showed that the content of VEGF, Ki-67 Expression decreased. Conclusion: Weianning Granule can inhibit tumor angiogenesis by inhibiting the expression of VEGF and Ki-67, so as to achieve anti-tumor effect.