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目的:探讨中西医结合治疗小儿难治性肺炎支原体肺炎(RMMP)的临床疗效及对白细胞介素-6(IL-6)和转化生长因子-β1(TGF-β1)的影响。方法:将74例RMMP患儿随机分为治疗组和对照组。对照组37例采用西医治疗方案,治疗组37例采用中西医结合治疗方案,在对照组治疗基础上加服小儿清肺止咳咳汤,1剂/d,疗程2周。观察临床症状、体征,评价临床疗效,检测治疗前后IL-6和TGF-β1变化。结果:治疗组在退热时间,咳嗽减轻时间,肺部罗音消失时间方面均低于对照组(P<0.05);治疗组总有效率为100.0%,对照组的81.1%,治疗组优于对照组(P<0.05);疗后两组IL-6水平显著下降(P<0.05),治疗组下降程度优于对照组(P<0.05);疗后治疗组TGF-β1水平与疗前相当,对照组TGF-β1水平持续升高(P<0.05)。结论:中西医结合治疗小儿难治性肺炎支原体肺炎(RMMP)有较好的临床疗效,其作用机制可能与其调节患儿机体免疫功能有关。
Objective: To investigate the clinical efficacy and the effect of IL-6 and TGF-β1 on the treatment of pediatric refractory Mycoplasma pneumoniae Mycoplasma pneumonia (PMPMP) with integrated traditional Chinese and western medicine. Methods: 74 cases of RMMP were randomly divided into treatment group and control group. In the control group, 37 cases were treated with western medicine. 37 cases in the treatment group were treated with integrated traditional Chinese and western medicine. On the basis of the control group, children were given Qingfeizhike Decoction, 1 dose / d for 2 weeks. The clinical symptoms and signs were observed, the clinical efficacy was evaluated, and the changes of IL-6 and TGF-β1 before and after treatment were detected. Results: The treatment group was lower than the control group in the time of antipyretic, cough relief and disappearance of pulmonary rales (P <0.05). The total effective rate was 100.0% in the treatment group and 81.1% in the control group, and the treatment group was superior to the control group (P <0.05). After treatment, the levels of IL-6 in the two groups were significantly decreased (P <0.05), and the reduction in the treatment group was better than that in the control group (P <0.05). After treatment, the levels of TGF- , While the level of TGF-β1 in control group continued to increase (P <0.05). Conclusion: Integrative Chinese medicine treatment of children with intractable pneumonia mycoplasma pneumonia (RMMP) has a better clinical efficacy, its mechanism may be related to its regulation of immune function in children.