本文叙述了用苯胺合成菸酸的方法。苯胺与甘油环化合成喹啉时,加入相当于1/20苯胺量的硫酸铜作催化剂,在185-190℃油浴中迴流3小时,产量以苯胺计算为98-107%高于文献记载(产量84-91%)。用高锰酸钾氧化喹啉制备喹啉酸产量50%(文献产量52-53%)。喹啉酸在155-160℃烘箱中脱羧制备菸酸产量达100%,熔点235-236℃(文献记载为234-237,236.6℃)。 This article describes the synthesis of niacin from aniline. When aniline and glycerol were cyclized to synthesize quinoline, copper sulfate corresponding to 1/20 aniline amount was added as a catalyst and refluxed in an oil bath at 185-190 ° C for 3 hours. The yield was 98-107% in terms of aniline, higher than that reported in the literature Yield 84-91%). Quinolinic acid was produced in a yield of 50% (52-53% yield) by oxidation of quinoline with potassium permanganate. Quinolinic acid was decarboxylated in an oven at 155-160 ° C to produce 100% yield of niacin, mp 235-236 ° C (literature 234-237, 236.6 ° C).