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目的:观察非器官特异性自身抗体对慢性丙型肝炎抗病毒疗效的影响。方法:回顾性分析慢性丙型肝炎合并自身抗体阳性患者32例,以同期住院的年龄及性别相匹配的自身抗体阴性患者32例作为对照,观察其治疗结束病毒应答(ETVR)、复发(Relapse)及持续病毒应答(SVR)。结果:观察组及对照组ETVR、SVR分别为78.1%、71.9%及59.4%、53.1%。具有统计学差异。结论:自身抗体阴性的慢性丙型肝炎患者对干扰素联合利巴韦林治疗比合并自身抗体阳性患者具有更好的疗效。
Objective: To observe the effect of non-organ specific autoantibodies on the antiviral effect of chronic hepatitis C virus. Methods: Thirty-two patients with chronic hepatitis C complicated with autoantibodies were retrospectively analyzed. Twenty-three patients with autoantibodies negative in the same period of hospitalization were enrolled in this study. ETVR, Relapse, And continuous virus response (SVR). Results: The ETVR and SVR of observation group and control group were 78.1%, 71.9% and 59.4%, 53.1% respectively. With statistical differences. CONCLUSIONS: Patients with autoantibodies negative for chronic hepatitis C have a better response to interferon plus ribavirin than those with autoantibodies.