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1990年Sessa等曾报道,胰腺导管癌常表达胃肠上皮细胞各种标志物。组织蛋白酶E(CTSE)系人胃粘膜内4种免疫学不同组型的天门冬氨酸蛋白酶之一。除组织蛋白酶E外,胃天门冬氨酸蛋白酶包括胃蛋白酶原A和C以及组织蛋白酶D。CTSE与另3种胃天门冬氨酸酶不同,是一种非分泌性的细胞内的非溶酶体蛋白酶,在胃表层上皮细胞中含量极高。本文作者对胰腺导管癌CTSE表达作了研究,以观察胰液内CTSE的诊断有用性。 选择经超声波、CT、ERCP和超声内窥镜诊断的67例胰腺病变患者。其中11例确诊为胰腺导管癌患者中男5例,女6例,年龄54～70岁,平均61.3岁。10例产粘液性瘤中男4例,女6例,年龄48～78岁,平均
In 1990, Sessa et al. reported that pancreatic ductal carcinoma often expresses various markers of gastrointestinal epithelial cells. Cathepsin E (CTSE) is one of four immunogenic different types of aspartic proteases in the human gastric mucosa. In addition to cathepsin E, gastric aspartic proteases include pepsinogen A and C, and cathepsin D. Unlike the other three gastric aspartases, CTSE is a non-secreting intracellular non-lysosomal protease that is highly expressed in epithelial cells of the stomach. The authors studied the CTSE expression of pancreatic ductal carcinoma to observe the usefulness of CTSE in pancreatic juice. Sixty-six patients with pancreatic lesions diagnosed by ultrasound, CT, ERCP, and ultrasound were selected. Among 11 patients diagnosed with pancreatic ductal carcinoma, 5 were males and 6 were females, aged 54 to 70 years, with an average of 61.3 years. Among 10 cases of myxoid neoplasms, 4 were male and 6 were female. Aged 48 to 78 years old.