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[目的]探讨在阿司匹林和低分子肝素等常规用药基础上加用氯吡格雷治疗短暂性脑缺血发作患者的疗效。[方法]选择短暂性脑缺血发作患者100例,随机分成观察组和对照组。两组患者都给予相同的对症基础治疗。对照组采用低分子肝素和阿司匹林治疗;观察组在对照组的基础上加用氯吡格雷。两组均于治疗前和治疗后2周检查凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)定量及血小板计数(PLT),并分别评定疗效。[结果]观察组临床总有效率为92.00%高于对照组的临床总有效率72.00%,具有统计学差异(P﹤0.01)。观察组和对照组的治疗方法对出凝血指标均无影响(P﹥0.05)。两组不良反应率差异不显著(P﹥0.05)。[结论]在阿司匹林和低分子肝素等常规用药基础上加用氯吡格雷治疗短暂性脑缺血发作患者疗效佳,而且也具有良好的安全性,值得临床进一步推广。
[Objective] To investigate the efficacy of clopidogrel in the treatment of transient ischemic attacks on the basis of conventional drugs such as aspirin and low molecular weight heparin. [Method] One hundred patients with transient ischemic attack were randomly divided into observation group and control group. Both groups were given the same symptomatic treatment. The control group was treated with low molecular weight heparin and aspirin. The observation group was given clopidogrel on the basis of the control group. Prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB) quantification and platelet count (PLT) were measured in both groups before and 2 weeks after treatment. [Results] The total clinical effective rate was 92.00% in the observation group and 72.00% in the control group, with statistical significance (P <0.01). The treatment of observation group and control group had no effect on coagulation index (P> 0.05). Adverse reactions between the two groups showed no significant difference (P> 0.05). [Conclusion] Clopidogrel is effective in treating patients with transient ischemic attack on the basis of conventional medication such as aspirin and low molecular weight heparin. It also has good safety and is worth further promotion in clinic.