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糖尿病肾病(DN)是糖尿病常见的微血管并发症,越来越多的实验及临床研究表明氧化应激在DN的发生和发展中扮演着重要的角色。糖尿病患者由于代谢紊乱,自由基产生增多,同时高血糖还可以影响清除自由基的各种抗氧化酶的活性及表达,也可以导致自由基水平升高,而升高的自由基又可以损伤肾脏组织,从而导致了DN的发生。有关抗氧化剂治疗DN的研究较多,他汀类降脂药、血管紧张素转换酶抑制剂、噻唑烷二酮等也被认为有一定的肾脏保护作用,这也为DN的临床防治提供新的研究方向和治疗靶点。
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. More and more experimental and clinical studies have shown that oxidative stress plays an important role in the development and progression of DN. Diabetes mellitus due to metabolic disorders, increased free radicals, while high blood sugar can also affect the activity of various free radical scavenging enzyme and expression, can also lead to elevated free radicals, while the increased free radicals can damage the kidneys Organization, which led to the occurrence of DN. There are many studies about antioxidant treatment of DN, statin lipid-lowering drugs, angiotensin converting enzyme inhibitors, thiazolidinediones, etc. are also considered to have a protective effect of the kidney, which also provides a new study for the clinical control of DN Direction and treatment target.