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目的 探讨三维数字化导航穿刺技术在气管前腔静脉后(PTRC)间隙病变活检中的应用价值,提高穿刺活检的准确性与安全性.方法 回顾性分析2013年1月至2016年10月本院收治的90例PTRC间隙病变需穿刺活检的患者资料,44例患者采用三维数字化导航穿刺活检作为研究组;46例患者采用常规CT横断面引导下穿刺针活检作为对照组;采用x2检验比较两组病例的一次性穿刺成功率、并发症发生率、诊断正确率;采用t检验比较两组病例的手术时间.结果 研究组一次穿刺成功率、诊断正确率分别是84.09％ (37/44)、97.72％ (43/44),对照组分别为41.34％ (19/46)、71.74％ (33/46),前者明显高于后者(x2=17.52,11.56;P均＜0.05).研究组并发症发生率、手术时间分别为11.36％ (5/44)和(11.64 ±2.76)分钟,对照组分别为36.95％ (17/46)和(22.22±6.31)分钟,前者明显低于后者(x2=7.98,t=10.27;P均＜0.05).结论 三维数字化导航PTRC间隙病变穿刺活检明显提高了一次穿刺成功率和诊断正确率,使并发症发生率和穿刺时间明显降低,具有较高的准确性与安全性.“,”Objective Investigating the application of MSCT three-dimensional digital navigated biopsy technique,to promote the accuracy and safety in the pretracheal retrocaval space biopsy.Methods 90 patients were enrolled from January 2013 to October 2016 in a retrospective study.The research group included 44 patients who were treated by three-dimensional positioning and three-dimensional navigation needle biopsy.The control group included 46 patients who were treated by CT cross-sectional image positioning with conventional needle puncture.Puncture accuracy,one-time success rate of puncture,complications,diagnostic accuracy and operation time were compared between the two groups.Results Onetime puncture success rates and definitive diagnosis rate of the research group were 84.09％ (37/44) and 97.72％ (43/ 44),respectively;those of control group were 41.34％ (19/46) and 71.74％ (33/46).The former were higher than the latter (x2 =17.52,11.56;P all ＜ 0.05).The incidence of complications and operation time in research group were 11.36％ (5/44) and (11.64 ± 2.76) min,respectively;those of the control group were 36.95％ (17/46) and (22.22 ±6.31) min.The former were lower than the latter (x2 =7.98,t =10.27;P all ＜ 0.05).Conclusion MSCT three-dimensional digital navigated biopsy technique could significantly improve the one-time success rate of puncture and diagnostic accuracy of the pretracheal retrocaval space percutaneous needle biopsy.It is a novel,convenient,precise,and safe modality for navigated puncture biopsy.