脑静脉窦结构复杂,变异较大,其闭塞的各种动物实验模型各有优缺点,国内外尚没有一个较为公认的方案。实验发现脑静脉窦闭塞后主要出现颅内压增高、脑水肿等;阻塞上矢状窦后部,区域脑血流明显减少;静脉窦闭塞可造成脑功能的异常,其脑组织的病理形态亦发生改变,如水肿、神经元肿胀变性、线粒体破坏、内质网崩溃等。目前研究发现肝素、血管内皮生长因子、组织胞浆素原活化剂、C1酯酶抑制剂等药物干预脑静脉窦闭塞,可改善其闭塞后脑微循环,减轻脑组织损害。 Cerebral venous sinus complex structure, large variation, the occlusion of various animal models have their own advantages and disadvantages of experimental models at home and abroad yet a more recognized program. Experimental found that cerebral venous sinus occlusion after the main increase in intracranial pressure, cerebral edema; obstruction of the posterior sagittal sinus, regional cerebral blood flow was significantly reduced; sinus occlusion can cause abnormal brain function, the pathological morphology of the brain tissue also Changes, such as edema, neuronal swelling and degeneration, mitochondrial damage, endoplasmic reticulum collapse and so on. The current study found that heparin, vascular endothelial growth factor, tissue plasminogen activator, C1 esterase inhibitors and other drugs interfere with cerebral venous sinus occlusion can improve its cerebral microcirculation after occlusion, reduce brain damage.