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目的:探讨在控制性超促排卵中克罗米芬(CC)联合高孕激素促排卵方案抑制早发LH峰的临床效果。方法:回顾性分析126名行体外受精/卵胞质内单精子显微注射(IVF/ICSI)取卵周期的患者,分为CC联合高孕激素促排卵组(试验组,n=63)和短方案治疗组(对照组,n=63)。观察过早LH峰发生率、促排卵中Gn用量和用药天数、获卵数、成熟卵数、内分泌及胚胎试验室结果。结果:试验组获卵数、成熟卵数、有效胚胎数、生化妊娠率、临床妊娠率、胚胎种植率与对照组比较均无统计学差异(P<0.05)。所有对象在促排卵过程中未监测到早发LH峰,试验组月经第9~10日和诱发排卵日LH水平与基础值间无统计学差异(P<0.05)。试验组Gn用量和用药天数均高于对照组(P<0.05)。结论:CC联合高孕激素促排卵方案可以有效抑制早发LH峰,促排卵过程中LH水平平稳,且可以获得有发育潜能的胚胎。
Objective: To investigate the clinical effect of clomiphene citrate (CC) in combination with high progesterone ovulation induction on the control of early LH peak in controlled ovarian hyperstimulation. Methods: A total of 126 IVF / ICSI ovulation cycles of in vitro fertilization / intracytoplasmic sperm injection were retrospectively analyzed and divided into CC combined with high progestogen ovulation induction group (experimental group, n = 63) and short Treatment group (control group, n = 63). To observe the incidence of premature LH peak, ovulation in the amount of Gn and medication days, the number of oocytes, mature eggs, endocrine and embryo laboratory results. Results: The number of oocytes, number of mature eggs, number of effective embryos, biochemical pregnancy rate, clinical pregnancy rate and embryo implantation rate of the experimental group were not significantly different from those of the control group (P <0.05). All subjects did not detect early LH peak during ovulation induction. There was no significant difference (P <0.05) between the LH level on the 9th and 10th days and ovulation day in the experimental group. The experimental group Gn dosage and the number of days were higher than the control group (P <0.05). CONCLUSION: CC combined with progesterone-induced ovulation induction can effectively inhibit the early LH peak, LH level during ovulation induction is stable, and embryos with developmental potential can be obtained.