20世纪80年代中期Barker首次提出了冠状动脉粥样硬化性心脏病(冠心病)、糖尿病、高血压等慢性成人疾病的“胎儿起源”假说。假说认为成年期的多种慢性疾病起源于胎儿期胎儿对宫内不良环境的适应性反应,包括代谢、激素的产生、组织器官对激素的敏感性方面的改变,这些都将影响各器官的生长发育,导致整 In the mid-1980s Barker first proposed the “fetal origin” hypothesis of chronic adult diseases such as coronary atherosclerotic heart disease (CHD), diabetes and hypertension. Hypothesis that a variety of chronic diseases in adulthood originated in the fetus fetuses unfavorable environmental adaptation to the uterus, including metabolism, hormone production, tissue and organ hormone sensitivity changes, which will affect the growth of various organs Development, leading to the whole