【摘 要】
：
目的 探讨肝脾体积改变对早期诊断肝纤维化及肝硬化的应用价值.方法 137例受检者接受多层螺旋CT(MSCT)动态增强检查,其中40例为无肝脏疾病的肝移植供体(对照组).63例经肝穿刺
【机 构】
：
上海交通大学医学院附属瑞金医院放射科,感染科,移植科
论文部分内容阅读
目的 探讨肝脾体积改变对早期诊断肝纤维化及肝硬化的应用价值.方法 137例受检者接受多层螺旋CT(MSCT)动态增强检查,其中40例为无肝脏疾病的肝移植供体(对照组).63例经肝穿刺活检证实为肝纤维化患者,根据Ishak评分系统再分为轻度肝纤维化组(F≤2,44例)和显著肝纤维化组(F≥3,19例),34例经临床或影像学表现诊断为肝硬化失代偿(肝硬化组).进行全肝体积(TLV)、右半肝体积(RV)、左外叶体积(LLV)、左内叶体积(LMV)、尾状叶体积(CV)及脾脏体积(SV)测定,并分别计算上述各体积与TLV的比值.结果 对照组、轻度肝纤维化组、显著肝纤维化组及肝硬化组的TLV分别为1470.38、1239.99、1219.76、1078.21 cm3,RV分别为933.34、799.74、765.22、543.73 cm3,LMV分别为216.20、184.69、179.44、163.12 cm3,均呈降低趋势;而SV分别为256.29、284.41、343.13、863.38 cm3,CV/TLV分别为3.09%、3.20%、3.58%、4.16%,SV/TLV分别为17.53%、22.91%、28.80%、82.91%,均呈升高趋势.除轻度肝纤维化及显著肝纤维化组间差异无统计学意义(P＞0.05)外.其他各组间差异均有统计学意义(P＜0.05).TLV、LMV、SV、RV、RV/TLV、LLV/TLV、CV/TLV及SV/TLV与肝纤维化及肝硬化分期显著相关.结论 肝脾体积改变及肝脏各叶、SV/TLV有助于早期诊断肝纤维化及肝硬化.
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