BACKGROUND:Endosymbionts are microorganisms present in all plant species,and constitute the subject of interest among the scientific community.These symbionts have gained considerable attention in recent years,owing to their emerging biological roles.Global challenges,such as antimicrobial resistance,treatment of infectious diseases such as HIV and tuberculosis,cancer,and many genetic disorders,exist.Endosymbionts can help address these challenges by secreting valueadded bioactive compounds with various activities.OBJECTIVE:Herein,we describe the importance of plants inhabiting Siberian niches.These plants are considered to be among the least studied organisms in the plant kingdom worldwide.Barcoding these plants can be of interest for exploring bioactive endosymbionts possessing myriad biological properties.METHODS:A systematic survey of relevant scientific reports was conducted using the PubMed search engine.The reports were analyzed,and compiled to draft this review.RESULTS:The literature survey on Siberian plants regarding endosymbionts included a few reports,since extremely few exploratory studies have been conducted on the plants in these regions.Studies on the endosymbionts of these plants are highly valuable,as they report potent endosymbionts possessing numerous biological properties.Based on these considerations,this review aims to create awareness among the global scientific community working on related areas.CONCLUSION:This review could provide the basis for barcoding novel endosymbionts of Siberian plants and their ecological importance,which can be exploited in various sectors.The main purpose of this review is to create awareness of Siberian plants,which are among the least studied organisms in the plant kingdom,with respect to endosymbionts,among the scientific community.