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肝硬化是一种常见的慢性肝病,是多原因引起的肝脏损害,肝星状细胞(HSC)在肝硬化、肝纤维化病程中起关键作用。多种信号分子都能导致HSC的活化激活。近年来的研究发现,尽管不同病因导致肝病的发病机制不同,但肝纤维化发生的共同途径均是HSC。对HSC激活的多信号分子复杂网络系统的研究,可以为HSC的基因治疗提供系统的理论基础,从而使HSC的基因治疗具有高靶向性、高效性和低免疫原性,达到理想的肝纤维化治疗效果。
Cirrhosis is a common chronic liver disease caused by multiple causes of liver damage. Hepatic stellate cells (HSCs) play a key role in the pathogenesis of cirrhosis and liver fibrosis. A variety of signaling molecules can lead to the activation of HSC activation. In recent years, the study found that although the pathogenesis of liver disease caused by different causes are different, but common pathways of liver fibrosis are HSC. HSC-activated multi-signaling molecule complex network system can provide a systematic theoretical basis for the gene therapy of HSC, so that the HSC gene therapy with high targeting, high efficiency and low immunogenicity, to achieve the desired liver fiber Therapeutic effect.