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目的:观察西酞普兰治疗肺癌术后抑郁症的临床疗效及安全性。方法:选取肺癌术后伴发抑郁症的患者114例,按随机数字表法分为观察组和对照组,各57例。对照组患者术后给予营养支持、平衡电解质等常规治疗,未服用抗抑郁药物;观察组患者术后口服氢溴酸西酞普兰片20 mg,qd。两组患者均连续治疗6周。观察两组患者临床疗效及治疗前后汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、健康调查量表(SF-36)评分,并记录不良反应发生情况。结果:观察组总有效率为87.72%,显著高于对照组的71.93%,差异有统计学意义(P<0.05);两组患者治疗前HAMD评分、HAMA评分及SF-36各项评分和总分比较,差异无统计学意义(P>0.05);两组患者治疗后HAMA评分、HAMD评分显著降低,且观察组显著低于对照组,SF-36各项评分和总分显著升高,且观察组显著高于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:西酞普兰治疗肺癌术后抑郁症的疗效显著,能明显改善患者精神状态和生存质量,且安全性较好。
Objective: To observe the clinical efficacy and safety of citalopram in the treatment of postoperative depression of lung cancer. Methods: A total of 114 patients with depression after lung cancer surgery were divided into observation group and control group according to the random number table method, with 57 cases in each group. Patients in the control group were given nutritional support, balanced electrolyte and other conventional treatment, did not take antidepressants; observation group patients oral administration of citalopram hydrobromide tablets 20 mg, qd. Two groups of patients were treated for 6 weeks. The clinical efficacy and HAMD score, Hamilton Anxiety Scale (HAMA) score and Health Surveys Scale (SF-36) scores of two groups were observed before and after treatment, and the incidence of adverse reactions was recorded. Results: The total effective rate of observation group was 87.72%, which was significantly higher than that of control group (71.93%), the difference was statistically significant (P <0.05); HAMD score, HAMA score and SF-36 scores and total score There was no significant difference between the two groups (P> 0.05). HAMA scores and HAMD scores decreased significantly in both groups after treatment, and the scores in the observation group were significantly lower than those in the control group The observation group was significantly higher than the control group, the difference was statistically significant (P <0.05). No obvious adverse reactions occurred in both groups. Conclusion: Citalopram treatment of postoperative depression in patients with lung cancer significantly effect, can significantly improve the patient’s mental state and quality of life, and safety is better.