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衰竭心脏在发展的不同阶段,心肌细胞线粒体嵴膜磷脂呈现不同程度的脱失等损伤性改变[中华心血管病杂志,1993,21:209.]。本文观察了容量超负荷心脏卡托普利不同时期干预对心肌细胞线粒体膜磷脂损伤的作用,以及与心脏泵功能的关系,为心力衰竭的选择性治疗提供依据。 1 材料与方法将67只8～12周龄SD大鼠随机分为早期干预和后期干预两大组,每大组内设同龄假手术组、非干预组和干预组。干预组及非干预组行腹主动脉～后腔静脉造瘘术,造成容量超负荷心力衰竭模型。早期干预在造痿后立即给药,后期干预在术后4周的心脏代偿时再干预。干预药物为卡托普利(中美上海施贵宝公司生产),按50mg·kg~(-1)/日通过饮水给予。总干预时间8周。所有动物在观察终点(分别为术后8周、12周)麻醉
Failure of the heart at different stages of development, myocardial mitochondrial cristae phospholipid showed varying degrees of degeneration and other injury changes [Journal of Cardiovascular Diseases, 1993,21: 209.]. This paper investigates the effect of captopril in different periods on the mitochondrial membrane phospholipid damage in cardiomyocytes and its relationship with cardiac pump function in order to provide evidence for the selective treatment of heart failure. MATERIAL AND METHODS One hundred and sixty Sprague-Dawley rats aged 8-12 weeks were randomly divided into two groups: early intervention and late intervention. Each group was divided into the same group of sham operation group, non-intervention group and intervention group. The intervention group and the non-intervention group underwent abdominal aorta to vena cava ostomy, resulting in a model of volume overload heart failure. Early intervention is given immediately after impotence, and later intervention is resumed after 4 weeks of cardiac compensation. The intervention drug was captopril (Sino-US Shanghai Squibb Company), by 50mg · kg -1 (-1) / day by drinking water. The total intervention time is 8 weeks. All animals were anesthetized at the end of the study (8 and 12 weeks after surgery, respectively)